Robin van Persie will be captain for the side's first match of the season against the Tynesiders on Saturday in Fabregas' absence.
Without Fabregas and Nasri, Wenger will start his Premier League campaign with a shortage of personnel in midfield.
Jack Wilshere, Abou Diaby and Theo Walcott are suffering injuries, while Denilson has returned to former club Sao Paulo on loan..dewatangkas
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After the visit to St James' Park, Arsenal play Liverpool and Manchester United in the Premier League with two legs of their Champions League qualifier against Udinese completing their first five matches.